RM, MW and GLM analysed and interpreted the data, revised the draft and approved the final version to be published.įunding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors. AC, RA, GP, YO, SS-M, LP, CLJ, LB, SA, RB, MD acquired the data, revised the draft and approved the final version to be published.
PL and SW designed the study acquired, analysed and interpreted the data revised the draft and approved the final version to be published.
The combined factor ‘ODS or bilateral or recurrent ON’ was the best compromise between PPV (31% (95% CI 14% to 48%)) and NPV (100% (95% CI 100% to 100%)).Ĭontributors J-BD designed the study acquired, analysed and interpreted the data wrote the draft invited coauthors to revise the draft and approved the final version to be published. To predict MOG+ON, the positive predictive values (PPVs) of male sex, ODS and bilateral involvement were 29% (95% CI 9% to 48%), 41% (95% CI 18% to 65%) and 40% (95% CI 10% to 70%), respectively, while the negative predictive values (NPV) were 93% (95% CI 86% to 100%), 96% (95% CI 90% to 100%) and 91% (95% CI 83% to 99%), respectively. Compared with MS and clinically isolated syndrome, MOG+ON had no female preponderance (67% of men in case of MOG+ON and 22% of men in case of MS and clinically isolated syndrome, p<0.05) were more often bilateral (44% vs 3%, p <0.005) and associated with optic disc swelling (ODS) (78% vs 14%, p <0.001). MOG-Ab prevalence was 14% (9/65) during an acute ON and 13% (7/55) after exclusion of patients already diagnosed with multiple sclerosis (MS) (8) or MOG+ON (2). Results Sixty-five patients were included.
6 Ophtalmologie, Centre Hospitalier de Saint Nazaire, Saint Nazaire, France.5 Ophtalmologie, Centre Hospitalier Départemental la Roche-sur-Yon Luçon Montaigu, La Roche-sur-Yon, France.4 Neurologie, Centre Hospitalier de Mans, Le Mans, France.3 Ophtalmologie, Centre Hospitalier de Mans, Le Mans, France.2 Ophtalmologie, Centre Hospitalier Universitaire d'Angers, Angers, France.1 Ophtalmologie, Centre Hospitalier Universitaire de Nantes, Nantes, France.